منابع مشابه
The impact of heterochromatin on DSB repair.
DNA NHEJ (non-homologous end-joining) is the major DNA DSB (double-strand break) repair pathway in mammalian cells. Although NHEJ-defective cell lines show marked DSB-repair defects, cells defective in ATM (ataxia telangiectasia mutated) repair most DSBs normally. Thus NHEJ functions independently of ATM signalling. However, approximately 15% of radiation-induced DSBs are repaired with slow kin...
متن کاملUbcH7 regulates 53BP1 stability and DSB repair.
DNA double-strand break (DSB) repair is not only key to genome stability but is also an important anticancer target. Through an shRNA library-based screening, we identified ubiquitin-conjugating enzyme H7 (UbcH7, also known as Ube2L3), a ubiquitin E2 enzyme, as a critical player in DSB repair. UbcH7 regulates both the steady-state and replicative stress-induced ubiquitination and proteasome-dep...
متن کاملThe RABiT: high-throughput technology for assessing global DSB repair.
At the Center for High-Throughput Minimally Invasive Radiation Biodosimetry, we have developed a rapid automated biodosimetry tool (RABiT); this is a completely automated, ultra-high-throughput robotically based biodosimetry workstation designed for use following a large-scale radiological event, to perform radiation biodosimetry measurements based on a fingerstick blood sample. High throughput...
متن کاملStoichiometry of ubiquitin-binding proteins directs DSB repair
Comment on: Helchowski CM, et al. Cell Cycle 2013; 12:3749-58; PMID:24107634; http://dx.doi.org/10.4161/cc.26640 Christopher J Bakkenist and Cyrus Vaziri; Departments of Radiation Oncology and Pharmacology and Chemical Biology; University of Pittsburgh School of Medicine; Hillman Cancer Center; Pittsburgh, PA USA; Department of Pathology; University of North Carolina Chapel Hill; Chapel Hill, N...
متن کاملDNA DSB repair pathway choice: an orchestrated handover mechanism.
DNA double strand breaks (DSBs) are potential lethal lesions but can also lead to chromosome rearrangements, a step promoting carcinogenesis. DNA non-homologous end-joining (NHEJ) is the major DSB rejoining process and occurs in all cell cycle stages. Homologous recombination (HR) can additionally function to repair irradiation-induced two-ended DSBs in G2 phase. In mammalian cells, HR predomin...
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ژورنال
عنوان ژورنال: Nature Cell Biology
سال: 2009
ISSN: 1465-7392,1476-4679
DOI: 10.1038/ncb1109-1279